Neurological & Psychological Disorders News on research and diagnostic developments in neuroscience. Gut Microbiome Changes Linked to Preclinical Alzheimer's Disease The study revealed several differences in the gut microbiomes of healthy individuals and people with preclinical Alzheimer's disease. Circular Genomics Sees More Direct PGx Assay Through Brain-Derived Circular RNA Premium The company sees a clearer path to clinical validation and reimbursement through molecules that more directly measure how drugs affect the brain. Multiplex Meningitis/Encephalitis Panel Market Expanding Despite Lack of Stewardship Guidelines Premium The use of highly multiplexed PCR panels to detect pathogens causing brain infections is poised to increase with new competition in the market. Purdue Team Identifies Urinary Protein Markers for Parkinson's Disease Premium In work supported by the Michael J. Fox Foundation, the researchers identified protein markers for the condition in extracellular vesicles collected from urine. Alzheimer's Disease Analysis Leads to Modifiable Causal Factors Researchers used Mendelian randomization to find causal factors behind Alzheimer's disease, highlighting systolic blood pressure and high-density lipoprotein cholesterol. May 15, 2023 Early-Onset Alzheimer's Disease Symptoms Delayed by Rare Gene Variant May 8, 2023 PGx-Guided Dosing Can Lead to Faster Therapeutic Blood Levels of Antidepressants May 8, 2023 Vigil Neuroscience Launches No-Cost Genetic Counseling, Testing Program for Rare Neurologic Disorder Apr 24, 2023 Single-Cell, Spatial Genomics Studies Unravel Development of Fetal Spinal Cord Apr 20, 2023 Transcriptomic Data May Provide New Way to Classify, Compare Brain Disorders Apr 17, 2023 Schizophrenia Risk Genes Coexpressed Differently Across Lifetime, Brain Regions Mar 28, 2023 Schmidt Futures Gives $50M for Life Science Research Including Single-Cell Proteomics Institute Premium Mar 23, 2023 Genetic Risk of Substance Use Disorders Untangled in Large-Scale GWAS Meta-Analysis Mar 13, 2023 Protein-Truncating Variants Confer Schizophrenia Risk Across Human Populations Mar 6, 2023 Exome Sequencing for Cerebral Palsy Has Sufficient Diagnostic Yield for First-Tier Test Feb 22, 2023 APOE Missense Variant Linked to Increased Alzheimer's Disease Risk in African Americans Feb 17, 2023 Large-Scale Study Reveals Genetics of White Matter Connections in the Human Brain Feb 15, 2023 Incite Health Acquires Mental Illness Pharmacogenetics Firm CNSDose Jan 31, 2023 Ampel BioSolutions, Duke Researchers Establish Fibromyalgia Gene Signature Premium Jan 17, 2023 Rare Single-Gene Variants Confer High Risk for Mental Health Conditions, Geisinger Study Shows Premium Jan 12, 2023 Linus Biotechnology Raises $16M in Series A Funding Jan 9, 2023 Centogene Strikes Deals With Premier Research, Denali Therapeutics for Clinical Trials Dec 15, 2022 Late-Onset Ataxia Linked to New Repeat Expansion in FGF14 Gene Dec 14, 2022 Study Links Maternal Mental Illness-Related Variants to Perinatal Risk Factors For Offspring Dec 14, 2022 GWAS of Veterans Ties Four Genetic Loci to Risk of Suicidal Thoughts, Behaviors Load More Breaking News Helix, St. Luke's University Health Network Partner on Population Health Study Exome Sequencing Study Suggests Early Menopause May Not Be Monogenic New Products Posted to GenomeWeb: Tempus, GenScript, RealSeq Biosciences, 23andMe People in the News at Biocept, Arcensus, TATAA Biocenter, Quantum-Si, LetsGetChecked, More In Brief This Week: Qiagen, Mainz Biomed, Quest Diagnostics, Haystack Oncology, Becton Dickinson The Scan Cystatin C Plays Role in Immunosuppression, Cancer Immunotherapy Failure, Study Finds A study in Cell Genomics provides insight into how glucocorticoids can lead to cancer immunotherapy failure via cystatin C production. Aging, Species Lifespan Gene Expression Signatures Overlap An Osaka Metropolitan University team reports in Nucleic Acids Research that transcriptional signatures of aging and maximum lifespan have similarities. Splicing Subgroup Provides Protocols for Evaluating Splicing Variant Data The group presents their approach on how to apply evidence codes to splicing predictions and other data in the American Journal of Human Genetics. Single-Cell Transcriptomic Atlas of Mouse Cochlea to Aid Treatment Development Researchers in PNAS conducted single-cell and single-nuclear sequencing of about 120,000 cells at three key timepoints in cochlear development to generate a transcriptomic atlas.